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Title 

The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer

Authors 

Seon-Kyu KimKwangho KimJea Woon RyuTae Young RyuJung Hwa LimJ H OhJeong Ki MinJung Cho RokR HamamotoMi Young SonDae Soo KimHyun Soo Cho

Publisher 

Spandidos Publications

Issue Date 

2019

Citation 

International Journal of Oncology

Keywords 

Breast cancerCorrelationsEuchromatic histone-lysine N-methyltransferase 2Heat shock protein family D (Hsp60) member 1Prognostic value

Abstract 

Molecular classifications of breast cancer (BRC), such as human epidermal growth factor receptor 2 (HER2), luminal A and luminal B, have been developed to reduce unnecessary treatment by dividing patients with BRC into low- and high-risk progression groups. However, these methods do not cover all of the pathological characteristics of BRC, and investigations into novel prognostic/therapeutic markers are thus continually required. In this study, we identified the overexpression of the histone methyltransferase, euchromatic histone-lysine N-methyltransferase 2 (EHMT2) in BRC samples (n=1,222) and normal samples (n=113) derived from the TCGA portal by performing a BRC tissue microarray. EHMT2 overexpression was clearly associated with a poor prognosis in multiple cohorts of patients with BRC (total, n=1,644). Furthermore, the knockdown of EHMT2 expression affected cell apoptosis via the downregulation and re-localization of heat shock protein family D (Hsp60) member 1 (HSPD1). In addition, a statistically significant positive correlation between EHMT2 and HSPD1 expression was revealed in the clinical cohorts. On the whole, the findings of this study may assist the development of novel therapeutic strategies and provide a prognostic marker (EHMT2) for patients with BRC.

ISSN 

1019-6439

Link 

http://dx.doi.org/10.3892/ijo.2018.4608

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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