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Title 

Suppressive effects of rare ginsenosides, Rk1 and Rg5, on HMGB1-mediated septic responses

Authors 

J E KimWonhwa LeeS YangS H ChoM C BaekG Y SongJ S Bae

Publisher 

Elsevier

Issue Date 

2019

Citation 

Food and Chemical Toxicology

Keywords 

EndotheliumHMGB1SB1SB2Sepsis

Abstract 

High mobility group box 1 (HMGB1) is considered to be a late mediator of sepsis. The inhibition of HMGB1-mediated severe inflammatory response and restoration of endothelial integrity have emerged as attractive therapeutic strategies for the management of sepsis. Rare ginsenosides, Rk1 (SB1) and Rg5 (SB2), are among the main components of black ginseng and are prepared from ginsenoside Rd by steaming at 120?°C for 3?h. We examined the effects of SB1 and SB2 on HMGB1-mediated septic response and survival rate in a mouse model of sepsis. SB1 and SB2 were administered after challenge with HMGB1. SB1 and SB2 significantly reduced the release of HMGB1 in lipopolysaccharide (LPS)-activated primary human umbilical vein endothelial cells (HUVECS) via the SIRT1-mediated deacetylation of HMGB1. Moreover, SB1 and SB2 suppressed the production of TNF-α and IL-6 and the activation of NF-κB and ERK 1/2 by HMGB1. SB1 and SB2 also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice. In addition, treatment with SB1 and SB2 reduced the cecal ligation and puncture-induced release of HMGB1, sepsis-related mortality, and tissue injury in vivo. Our results indicate that SB1 and SB2 might be useful in the treatment of sepsis by targeting HMGB1.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2018.11.057

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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