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Title 

Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil

Authors 

S H KimH J WooM H LeeM ParkT NagendranK J RheeD LeeYeung Bae JinS W ChoiW D SeoJ B Kim

Publisher 

Elsevier

Issue Date 

2019

Citation 

Journal of Cereal Science

Keywords 

AnthocyaninBlack riceCyanidin 3-O-GlucosideHelicobacter pylori

Abstract 

It has been reported that cyanidin 3-O-glucoside (C3G) is an inhibitor of Helicobacter pylori toxin secretion. C3G is classified as an anthocyanin and is a major component of black rice extract (BRE). The present study aimed to identify a new functional food material to prevent H. pylori infection in Mongolian gerbil model. Toxicity in the liver and kidney were not detected after BRE administration (10 or 50 mg/kg). BRE treatment reduced bacterial colonization in animal gastric tissue, as well as infection signs as observed on the analysis of the hematological data. It was also found that the relative mRNA levels of the inflammatory cytokines were reduced in BRE-treated groups. These findings suggest that BRE acts as a potent inhibitor of H. pylori infection and pathogenesis in Mongolian gerbils. We propose that BRE may be used to manage gastroduodenal diseases caused by H. pylori infection.

ISSN 

0733-5210

Link 

http://dx.doi.org/10.1016/j.jcs.2018.11.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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