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Title 

Vaccine synergy with virus-like particle and immune complex platforms for delivery of human papillomavirus L2 antigen

 

HPV L2 항원 전달을 위한 VLP와 ICP의 백신 시너지

Authors 

A G DiamosD LariosL BrownJ KilbourneHyun Soon KimD SaxenaK E PalmerH S Mason

Publisher 

Elsevier

Issue Date 

2019

Citation 

Vaccine

Keywords 

Human papillomavirusMinor capsid proteinRecombinant immune complexVaccineVirus-like particle

Abstract 

Diverse HPV subtypes are responsible for considerable disease burden worldwide, necessitating safe, cheap, and effective vaccines. The HPV minor capsid protein L2 is a promising candidate to create broadly protective HPV vaccines, though it is poorly immunogenic by itself. To create highly immunogenic and safe vaccine candidates targeting L2, we employed a plant-based recombinant protein expression system to produce two different vaccine candidates: L2 displayed on the surface of hepatitis B core (HBc) virus-like particles (VLPs) or L2 genetically fused to an immunoglobulin capable of forming recombinant immune complexes (RIC). Both vaccine candidates were potently immunogenic in mice, but were especially so when delivered together, generating very consistent and high antibody titers directed against HPV L2 (>1,000,000) that correlated with virus neutralization. These data indicate a novel immune response synergy upon co-delivery of VLP and RIC platforms, a strategy that can be adapted generally for many different antigens.

ISSN 

0264-410X

Link 

http://dx.doi.org/10.1016/j.vaccine.2018.11.021

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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