상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Identification of novel immunogenic proteins against Streptococcus parauberis in a zebrafish model by reverse vaccinology

Authors 

Young Su KimN K YoonN KarisaS H SeoJeong Soo LeeS S YooI J YoonY C KimHong-Weon LeeJungoh Ahn

Publisher 

Elsevier

Issue Date 

2019

Citation 

Microbial Pathogenesis

Keywords 

Metal ABC transporter substrate-binding lipoproteinReverse vaccinologyStreptococcus parauberisSubunit vaccineZebrafish

Abstract 

Streptococcus parauberis is the major infectious agent of streptococcosis in the olive flounder (Paralichthys olivaceus), causing serious economic damage. In this study, we identified potential vaccine candidates against S. parauberis by reverse vaccinology. In total, the 2 out of 21 proteins were identified as vaccine candidates from two available S. parauberis genomes. The membrane-anchored protein SEC10/PgrA and the metal ABC transporter substrate-binding lipoprotein mtsA were potent antigenic proteins based on western blotting with mouse-derived antiserum against whole bacteria of S. parauberis serotypes I and II. In particular, metal ABC transporter substrate-binding lipoprotein (mtsA) showed similar protective immunity to that of whole-cell bacterins against S. parauberis in a zebrafish model. These results suggest that mtsA may be considered as a novel candidate in the development of vaccines against S. parauberis.

ISSN 

0882-4010

Link 

http://dx.doi.org/10.1016/j.micpath.2018.11.053

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)