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Title 

Bacterial clearance is enhanced by alpha2,3- and alpha2,6-sialyllactose via receptor-mediated endocytosis and phagocytosis

Authors 

Jimin KimYong Jae KimJae Wha Kim

Publisher 

American Society for Microbiology

Issue Date 

2019

Citation 

Infection and Immunity

Keywords 

HMObacterial clearancemacrophagephagocytosissialyllactose

Abstract 

Sialyllactose (SL) is a representative human milk oligosaccharide (HMO) of human breast milk. The roles of SL in infant brain development and immunity have been reported in previous studies. In this study, we identified the impact of SL on innate immunity. Our results showed that the administration of SL had significant efficacy on bacterial clearance in Pseudomonas aeruginosa K-infected mice. We also examined the role of SL in the human THP-1 macrophage-like cell line. SL effectively promoted receptor-mediated endocytosis and phagocytosis. Furthermore, SL accelerated the recruitment of Rac1 to the cell membrane, leading to the generation of reactive oxygen species for the elimination of phagocytosed bacteria. Our findings provide a new perspective on the role of SL in breast milk and suggest its application as a therapeutic agent to treat bacterial and viral infections.

ISSN 

0019-9567

Link 

http://dx.doi.org/10.1128/IAI.00694-18

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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