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Title 

Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis

Authors 

J RhoC S SeoH S ParkC U B WijerathneH Y JeongOg Sung MoonYoung Won SeoH Y SonYoung Suk WonH J Kwun

Publisher 

Elsevier

Issue Date 

2019

Citation 

Journal of Ethnopharmacology

Keywords 

ApoptosisBenign prostatic hyperplasiaErectyl disfunctionProliferationTestosterone propionate (Pubchem CID 5995)Ulmus macrocarpa Hancefinasteride (Pubchem CID 57363)

Abstract 

ETHNOPHARMACOLOGICAL RELEVANCE: Ulmus macrocarpa Hance (UMH), of the family Ulmaceae, is a deciduous tree, widely distributed throughout Korea. UMH has been used as a traditional oriental medicine in Korea for the treatment of urological disorders, including bladder outlet obstruction (BOO), lower urinary tract syndrome (LUTS), diuresis, and hematuria. To date, its possible protective effects against benign prostatic hyperplasia (BPH) have not been analyzed. AIM OF THE STUDY: This study investigated the effects of UMH on the development of BPH using a rat model of testosterone propionate (TP)-induced BPH. MATERIALS AND METHODS: BPH was induced by daily subcutaneous injections of testosterone propionate (TP) for four weeks. UMH was administrated daily by oral gavage at a dose of 150?mg/kg during the four weeks of TP injections. Animals were sacrificed, and their prostates were weighed and subjected to histopathological examination, TUNEL assay, and western blot analysis. RESULTS: Treatment of BPH-model rats with UMH significantly reduced prostate weight, serum testosterone concentration and dihydrotestosterone (DHT) concentration in prostate tissue. TP-induced prostatic hyperplasia and the expression of proliferating cell nuclear antigen (PCNA) were significantly attenuated in UMH-treated rats. In addition, UMH administration markedly induced the activation of caspases-3, -?8, and -?9 in prostate tissues of BPH rats, accompanied by upregulation of expression of Fas, Fas-associated protein with death domain (FADD), and Fas ligand (FasL) and a reduction in the ratio of B-cell lymphoma 2 (Bcl-2) to Bcl-2-associated X protein (Bax). CONCLUSIONS: UMH effectively inhibited the proliferation and promoted the apoptosis of prostate cells, suggesting it may be useful for the treatment of BPH.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2018.11.042

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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