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Title 

Effect of cinnamamides on atopic dermatitits through regulation of IL-4 in CD4+ cells

Authors 

E J ChoiYoung Bae RyuY TangBo Ram KimWoo Song LeeT DebnathM FanE K KimH S Lee

Publisher 

Informa Healthcare

Issue Date 

2019

Citation 

Journal of Enzyme Inhibition and Medicinal Chemistry

Keywords 

Atopic dermatitisCD4+ T cellsIL-4Th1/Th2 cytokinescinnamamides

Abstract 

This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing na?ve clusters of differentiation (CD)4+ T cells, and decreased the cervical lymph node size and weight. Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biological activity.

URI 

https://doi.org/10.1080/14756366.2019.1569647

ISSN 

1475-6366

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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