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Title 

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

Authors 

S J ParkY I KimA ParkH I KwonE H KimY J SiM S SongChul Ho LeeK JungW J ShinJ ZengY ChoiJ U JungY K Choi

Publisher 

Nature Publishing Group

Issue Date 

2019

Citation 

Nature Microbiology

Abstract 

Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the most dangerous pathogens by the World Health Organization, has 12-30% fatality rates with a characteristic thrombocytopenia syndrome. With a majority of clinically diagnosed SFTSV patients older than ~50?years of age, age is a critical risk factor for SFTSV morbidity and mortality. Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fully recapitulates the clinical manifestations of human infections. Whereas young adult ferrets (≤2?years of age) did not show any clinical symptoms and mortality, SFTSV-infected aged ferrets (≥4?years of age) demonstrated severe thrombocytopenia, reduced white blood cell counts and high fever with 93% mortality rate. Moreover, a significantly higher viral load was observed in aged ferrets. Transcriptome analysis of SFTSV-infected young ferrets revealed strong interferon-mediated anti-viral signalling, whereas inflammatory immune responses were markedly upregulated and persisted in aged ferrets. Thus, this immunocompetent age-dependent ferret model should be useful for anti-SFTSV therapy and vaccine development.

URI 

https://doi.org/10.1038/s41564-018-0317-1

ISSN 

2058-5276

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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