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Title 

Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity

Authors 

S C BaekM G KangJ E ParkJ P LeeH LeeHyung Won RyuC M ParkD ParkM L ChoSei-Ryang OhH Kim

Publisher 

Elsevier

Issue Date 

2019

Citation 

Bioorganic & Medicinal Chemistry Letters

Keywords 

Human monoamine oxidase AMolecular dockingOsthenolSelective competitive inhibitor

Abstract 

Osthenol (6), a prenylated coumarin isolated from the dried roots of Angelica pubescens, potently and selectively inhibited recombinant human monoamine oxidase-A (hMAO-A) with an IC50 value of 0.74??M and showed a high selectivity index (SI?>?81.1) for hMAO-A versus hMAO-B. Compound 6 was a reversible competitive hMAO-A inhibitor (Ki?=?0.26??M) with a potency greater than toloxatone (IC50?=?0.93??M), a marketed drug. Isopsoralen (3) and bakuchicin (1), furanocoumarin derivatives isolated from Psoralea corylifolia L., showed slightly higher IC50 values (0.88 and 1.78??M, respectively) for hMAO-A than 6, but had low SI values (3.1 for both). Other coumarins tested did not effectively inhibit hMAO-A or hMAO-B. A structural comparison suggested that the 8-(3,3-dimethylallyl) group of 6 increased its inhibitory activity against hMAO-A compared with the 6-methoxy group of scopoletin (4). Molecular docking simulations revealed that the binding affinity of 6 for hMAO-A (-8.5?kcal/mol) was greater than that for hMAO-B (-5.6?kcal/mol) and that of 4 for hMAO-A (-7.3?kcal/mol). Docking simulations also implied that 6 interacted with hMAO-A at Phe208 and with hMAO-B at Ile199 by carbon hydrogen bondings. Our findings suggest that osthenol, derived from natural products, is a selective and potent reversible inhibitor of MAO-A, and can be regarded a potential lead compound for the design of novel reversible MAO-A inhibitors.

URI 

https://doi.org/10.1016/j.bmcl.2019.01.016

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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