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Title 

The Galleria mellonella hologenome supports microbiota-independent metabolism of long-chain hydrocarbon beeswax

Authors 

Hyun Gi KongH H KimJoon Hui ChungJ H JunSoohyun LeeH M KimS JeonS G ParkJ BhakChoong-Min Ryu

Publisher 

Elsevier

Issue Date 

2019

Citation 

Cell Reports

Keywords 

Galleria mellonellagenome assemblyintestinal microbiotapolyethylenetranscriptomewax degradation

Abstract 

The greater wax moth, Galleria mellonella, degrades wax and plastic molecules. Despite much interest, the genetic basis of these hallmark traits remains poorly understood. Herein, we assembled high-quality genome and transcriptome data from G. mellonella to investigate long-chain hydrocarbon wax metabolism strategies. Specific carboxylesterase and lipase and fatty-acid-metabolism-related enzymes in the G. mellonella genome are transcriptionally regulated during feeding on beeswax. Strikingly, G. mellonella lacking intestinal microbiota successfully decomposes long-chain fatty acids following wax metabolism, although the intestinal microbiome performs a supplementary role in short-chain fatty acid degradation. Notably, final wax derivatives were detected by gas chromatography even in the absence of gut microbiota. Our findings provide insight into wax moth adaptation and may assist in the development of unique wax-degradation strategies with a similar metabolic approach for a plastic molecule polyethylene biodegradation using organisms without intestinal microbiota.

URI 

https://doi.org/10.1016/j.celrep.2019.02.018

ISSN 

2211-1247

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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