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Title 

BRM270 inhibits the proliferation of CD44 positive pancreatic ductal adenocarcinoma cells via downregulation of sonic hedgehog signaling

Authors 

D L HuynhH KohN ChandimaliJ J ZhangN KimT Y KangM GhoshM GeraY H ParkTaeho KwonD K Jeong

Publisher 

Hindawi Publishing Corporation

Issue Date 

2019

Citation 

Evidence-Based Complementary and Alternative Medicine

Abstract 

Pancreatic cancer has a poor survival rate as compared to other types of cancer. Surface marker CD44 plays important role in epithelial-mesenchymal transition and cancer stem cell phenotype. Therefore, targeting CD44 positive pancreatic cancer cells might enhance therapies effectiveness. Our previous studies indicated the antitumorigenesis effect of BRM270 in osteosarcoma, lung cancer, and glioblastoma; however there is no evidence on BRM270 impacts on pancreatic cancer growth. In this study, we investigated the effect of BRM270 on the isolated CD44 positive pancreatic ductal adenocarcinoma cells (CD44+ PDAC). Results showed that CD44 positive cells undergo apoptosis induced by BRM270. Moreover, BRM270 also inhibits stemness and metastasis traits in CD44+ PDAC via Sonic hedgehog signaling pathway and SALL4 expression. In vivo study indicated that tumor growth derived from CD44+ PDAC was suppressed as daily uptake by BRM270 5 mg/kg. These data suggest the alternative approach in antipancreatic tumorigenesis via herbal plants extract and selectively targeting CD44+ PDAC cells in tumor.

URI 

https://doi.org/10.1155/2019/8620469

ISSN 

1741-427X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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