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Title 

Suppressive activities of KC1-3 on HMGB1-mediated septic responses

Authors 

Wonhwa LeeO YuseokC LeeS Y JeongJ H LeeM C BaekG Y SongJ S Bae

Publisher 

Elsevier

Issue Date 

2019

Citation 

Biochemical Pharmacology

Keywords 

EndotheliumHMGB1KC1-3Sepsis

Abstract 

In the present study, several decursin analogues (KC1-3) were synthesized and evaluated in terms of their anti-septic activities on high mobility group box 1 (HMGB1)-mediated septic responses and survival rate in a mouse model of sepsis. KC1 and KC3, but not KC2, significantly reduced HMGB1 release in lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) and attenuated the cecal ligation and puncture (CLP)-induced release of HMGB1. Additionally, in vitro analyses revealed that KC1 and KC3 both alleviated HMGB1-mediated vascular disruptions and inhibited hyperpermeability in mice, and in vivo analyses revealed that KC1 and KC3 reduced sepsis-related mortality and tissue injury. Taken together, the present results suggest that KC1 and KC3 both reduced HMGB1 release and septic mortality and, thus, may be useful for the treatment of sepsis.

URI 

https://doi.org/10.1016/j.bcp.2019.02.027

ISSN 

0006-2952

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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