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Title 

Gene expression profile of olfactory transduction signaling in an animal model of human multiple sclerosis

Authors 

J KimM AhnY ChoiP EkanayakeC M ParkC MoonKyungsook JungA TanakaH MatsudaT Shin

Publisher 

Korean Society for Brain and Neural Science

Issue Date 

2019

Citation 

Experimental Neurobiology

Keywords 

Differentially expressed geneExperimental autoimmune encephalomyelitisOlfactory bulbOlfactory marker protein

Abstract 

Olfactory dysfunction occurs in multiple sclerosis in humans, as well as in an animal model of experimental autoimmune encephalomyelitis (EAE). The aim of this study was to analyze differentially expressed genes (DEGs) in olfactory bulb of EAE-affected mice by next generation sequencing, with a particular focus on changes in olfaction-related signals. EAE was induced in C57BL/6 mice following immunization with myelin oligodendrocyte glycoprotein and adjuvant. Inflammatory lesions were identified in the olfactory bulbs as well as in the spinal cord of immunized mice. Analysis of DEGs in the olfactory bulb of EAE-affected mice revealed that 44 genes were upregulated (and which were primarily related to inflammatory mediators), while 519 genes were downregulated; among the latter, olfactory marker protein and stomatin-like 3, which have been linked to olfactory signal transduction, were significantly downregulated (log2 [fold change] >1 and p-value <0.05). These findings suggest that inflammation in the olfactory bulb of EAE-affected mice is associated with the downregulation of some olfactory signal transduction genes, particularly olfactory marker protein and stomatin-like 3, which may lead to olfactory dysfunction in an animal model of human multiple sclerosis.

URI 

https://doi.org/10.5607/en.2019.28.1.74

ISSN 

1226-2560

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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