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Title 

PEGylated magnetic nano-assemblies as contrast agents for effective T2-weighted MR imaging

Authors 

B KangJaewoo LimH Y SonY ChoiTaejoon KangJuyeon JungY M HuhS HaamEun Kyung Lim

Publisher 

MDPI

Issue Date 

2019

Citation 

Nanomaterials

Keywords 

Magnetic resonance imagePEGylatedPoly(ethylene glycol)-poly(lactic acid)contrast agent

Abstract 

We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65?70 nm for an extended period (0 days: 68.8 ± 5.1 nm, 33 days: 69.2 ± 2.0 nm, and 44 days: 63.2 ± 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site.

URI 

https://doi.org/10.3390/nano9030410

ISSN 

2079-4991

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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