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Title 

Causes and mechanisms of hematopoietic stem cell aging

Authors 

Jungwoon LeeSuk Ran YoonIn Pyo ChoiHaiyoung Jung

Publisher 

MDPI AG

Issue Date 

2019

Citation 

International Journal of Molecular Sciences

Keywords 

differentiationhematopoietic stem cell agingrejuvenationself-renewal

Abstract 

Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells throughout the lifetime of an organism. Recent reports have suggested that HSCs are susceptible to age-related stress and gradually lose their self-renewal and regeneration capacity with aging. HSC aging is driven by cell-intrinsic and -extrinsic factors that result in the disruption of the immune system. Thus, the study of HSC aging is important to our understanding of age-related immune diseases and can also provide potential strategies to improve quality of life in the elderly. In this review, we delineate our understanding of the phenotypes, causes, and molecular mechanisms involved in HSC aging.

URI 

https://doi.org/10.3390/ijms20061272

ISSN 

1422-0067

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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