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Title 

Gastroprotective effects of plants extracts on gastric mucosal injury in experimental sprague-dawley rats

Authors 

Jung Uoon PahkJi Hoon KangM A A RahmanA HussainJ S ChoYoung Ik Lee

Publisher 

Hindawi Publishing Corporation

Issue Date 

2019

Citation 

BioMed Research International

Abstract 

Rubus crataegifolius (black raspberry, RF), Ulmus macrocarpa (elm, UL), and Gardenia jasminoides (cape jasmine, GJ) are well known for hundreds of years as folk medicines in China and Korea to treat various gastrointestinal disturbance. The present study evaluated the gastroprotective effects of these plants either single or in combination against HCl/EtOH-induced gastritis and indomethacin-induced ulcer in rat model. Stomach ulcer was induced by oral ingestions of HCl/EtOH or indomethacin. Treatment with RF, UL, and GJ separately or in combination was done 1?h before ulcer induction. On HCl/EtOH-induced gastritis RF, UL, and GJ at a dose of 150?mg/kg showed comparable antigastritis effect (less than 50% inhibition) with lesion index of 94.97±8.05, 108.48±11.51, and 79.10±9.77?mm compared to cimetidine (45.33±23.73?mm). However, the combination of RF, UL, and GJ at a dose of 150?mg/kg with a ratio of 50:50:50 showed remarkable antigastritis effect with 77% inhibition. The observed lesion index at a ratio of 50:50:50 was 23.34±9.11?mm similar to cimetidine (18.88±19.88?mm). On indomethacin-induced ulcer, RF and GJ showed 38.28% and 51.8% inhibition whereas UL showed around 17.73% inhibition at 150?mg/kg. Combination of RF, UL, and GJ at 150?mg/kg showed strong antigastritis effect with 83.71% inhibition. These findings suggest strong gastroprotective effect of combined extract. In addition, these plants showed significant antioxidant activity in DPPH scavenging assay and antilipid peroxidation activity. Combination of black raspberry, elm, and cape jasmine might be a significant systemic gastroprotective agent that could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

URI 

https://doi.org/10.1155/2019/8759708

ISSN 

2314-6133

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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