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Title 

SETDB1 regulates SMAD7 expression for breast cancer metastasis

Authors 

Tae Young RyuKwangho KimSeon-Kyu KimJ H OhJeong Ki MinCho Rok JungMi Young SonDae Soo KimHyun Soo Cho

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2019

Citation 

BMB Reports

Keywords 

Breast cancerMetastasisSETDB1

Abstract 

Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT/MET markers after knockdown of SETDB1. Moreover, gene network analysis showed that SMAD7 expression is regulated by SETDB1 levels, indicating that up-regulation of SMAD7 by SETDB1 knockdown inhibited BRC metastasis. Therefore, development of SETDB1 inhibitors and functional studies may help develop more effective clinical guidelines for BRC treatment.

URI 

https://doi.org/10.5483/BMBRep.2019.52.2.235

ISSN 

1225-8687

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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