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Title 

Bioinformatic analysis of regulation of natural antisense transcripts by transposable elements in human mRNA

Authors 

Jaeeun JungSugi LeeHyun Soo ChoKunhyang ParkJea Woon RyuMinah JungJeongkil KimHyeran KimDae Soo Kim

Publisher 

Elsevier

Issue Date 

2019

Citation 

Genomics

Keywords 

BioinformaticsHuman mRNAsNatural antisense transcriptsTransposable elements

Abstract 

Non-coding RNA is no longer considered to be "junk" DNA, based on evidence uncovered in recent decades. In particular, the important role played by natural antisense transcripts (NATs) in regulating the expression of genes is receiving increasing attention. However, the regulatory mechanisms of NATs remain incompletely understood. It is well-known that the insertion of transposable elements (TEs) can affect gene transcription. Using a bioinformatics approach, we identified NATs using human mRNA sequences from the UCSC Genome Browser Database. Our in silico analysis identified 1079 NATs and 700 sense-antisense gene pairs. We identified 179 NATs that showed evidence of having been affected by TEs during cellular gene expression. These findings may provide an understanding of the complex regulation mechanisms of NATs. If our understanding of NATs as modulators of gene expression is further enhanced, we can develop ways to control gene expression.

URI 

https://doi.org/10.1016/j.ygeno.2018.01.011

ISSN 

0888-7543

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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