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Title 

Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer

Authors 

Yun-Ji JeungK LeeH J LeeEunah KimMyung Jin SonJiwon AhnHan-Gyeul KimWantae KimHo-Joon LeeJ M KimKyung-Sook Chung

Publisher 

Wiley

Issue Date 

2019

Citation 

Cancer Science

Keywords 

gastric cancermetastasisPQLC2therapeutic targettumor formation

Abstract 

Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids. PQ loop repeat-containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of PQLC2 is critical to gastric cancer (GC) development in vitro and in vivo. Both PQLC2 mRNA and protein were overexpressed in GC tissues, especially of the diffuse type. Overexpression of PQLC2 promoted cell growth, anchorage independence, and tumor formation in nude mice. This was due to activation of MEK/ERK1/2 and PI3K/AKT signaling. Conversely, PQLC2 knockdown caused growth arrest and cell death of cancer cells and suppressed tumor growth in a mouse xenograft model. These results suggest that targeting PQLC2 is an effective strategy for GC treatment.

URI 

https://doi.org/10.1111/cas.13966

ISSN 

1347-9032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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