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Title 

Protective role of peroxiredoxin I in heat-killed Staphylococcus aureus-infected mice

Authors 

H N SunY LiuJ N WangC WangR LiuL Z KongX ZhenN ChandimaliY D CuiSun-Uk KimD S LeeDae Yeul YuJi-Su KimD K JeongTaeho KwonY H Han

Publisher 

International Institute of Anticancer Research (IIAR)

Issue Date 

2019

Citation 

In Vivo

Keywords 

Peroxiredoxin IStaphylococcus aureusintraperitonealinflammatoryknockout

Abstract 

Background/Aim: Staphylococcus aureus (S. aureus) is a major gram-positive pathogen, which can cause toxic and immunogenic injuries both in nosocomial and community-acquired infections. Peroxiredoxin (Prx) I plays crucial roles in cellular apoptosis, proliferation, and signal transduction as well as in immunoregulation. The present study aimed to investigate whether Prx I protects mice from death caused by the heat-killed Staphylococcus aureus. Materials and Methods: In the present study, we challenged the wild-type and Prx I-deficient mice with heat-killed S. aureus (HKSA). The effects of Prx I were evaluated by a series of in vitro and in vivo experiments including western blot, Haematoxylin and Eosin staining, splenocyte analysis and cytokines analysis. Results: Intra-peritoneal (ip) inoculation of HKSA resulted in increased mortality of Prx I-knockout (KO) mice with severe liver damage and highly populated spleens with lymphocytes. Furthermore, HKSA infections also bursted the production of both pro-inflammatory and antiinflammatory serum cytokines in Prx I KO compared to wildtype mice. Conclusion: Enhanced mortality of S. aureusinfected mice with Prx I deficiency suggested that Prx I may protect against the infection-associated lethality of mice.

URI 

https://doi.org/10.21873/invivo.11535

ISSN 

0258-851X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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