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Title 

Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells

 

발아된 귀리로부터 분리한 Avenanthramide C의 비만세포에서 항알러지 효과

Authors 

H DhakalE J YangSoyoung LeeM J KimM C BaekB LeeP H ParkT K KwonD KhangK S SongS H Kim

Publisher 

Nature Publishing Group

Issue Date 

2019

Citation 

Scientific Reports

Abstract 

Mast cells play a crucial role in allergic diseases via the release of inflammatory mediators, particularly histamine and pro-inflammatory cytokines. Avenanthramide (Avn) C, a polyphenol found mainly in oats, is known to exhibit various biological properties. In this study, we aimed to evaluate the effectiveness of Avn C from germinated oats against mast cell-mediated allergic inflammation. For the in vitro study, RBL-2H3, mouse bone marrow-derived mast cells and rat peritoneal mast cells were used. Avn C (1?100 nM) inhibited the immunoglobulin (Ig)E-stimulated mast cells degranulation by suppressing phosphorylation of phosphoinositide 3-kinase and phospholipase Cγ1 and decreasing intracellular calcium levels. It inhibited IgE-stimulated secretion of inflammatory cytokines via suppression of FcεRI-mediated signaling proteins Lyn, Syk, Akt, and nuclear factor-κB. To verify the effects of Avn C in vivo, ovalbumin-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. Oral administration of Avn C dose-dependently attenuated the ASA reactions, as evidenced by the inhibition of hypothermia and reduction of elevated serum histamine, IgE, and interleukin-4 levels. Avn C also inhibited the PCA reactions, such as ear swelling and plasma extravasation. Our results suggested that Avn C from germinated oats might be a possible therapeutic candidate for mast cell-mediated allergic inflammation.

URI 

https://doi.org/10.1038/s41598-019-43412-2

ISSN 

2045-2322

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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