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Title 

Small heterodimer partner controls the virus-mediated antiviral immune response by targeting CREB-binding protein in the nucleus

Authors 

Jae-Hoon KimJ E YoonC NikapitiyaT H KimM B UddinH C LeeYong-Hoon KimJung Hwan HwangK ChathurangaW A G ChathurangaH S ChoiC J KimJ U JungChul Ho LeeJ S Lee

Publisher 

Elsevier

Issue Date 

2019

Citation 

Cell Reports

Abstract 

Small heterodimer partner (SHP) is an orphan nuclear receptor that acts as a transcriptional co-repressor by interacting with nuclear receptors and transcription factors. Although SHP plays a negative regulatory function in various signaling pathways, its role in virus infection has not been studied. Here, we report that SHP is a potent negative regulator of the virus-mediated type I IFNsignaling that maintains homeostasis within the antiviral innate immune system. Upon virus infection, SHP interacts specifically with CREB-binding protein (CBP) in the nucleus, thereby obstructing CBP/b-catenin interaction competitively. Consequently, SHP-deficient cells enhance antiviral responses, including transcription of the type I IFN gene, upon virus infection. Furthermore, SHP-deficient mice show higher levels of IFN production and are more resistant to influenza A virus infection. Our results suggest that SHP is a nuclear regulator that blocks transcription of the type I IFN gene

URI 

https://doi.org/10.1016/j.celrep.2019.04.071

ISSN 

2211-1247

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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