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Title 

Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

Authors 

H J LeeYeonghoon SonM LeeC MoonS H KimI S ShinM YangS BaeJ S Kim

Publisher 

Elsevier

Issue Date 

2019

Citation 

Neural Regeneration Research

Keywords 

sodium butyrateradioprotectorionizing radiationhippocampal damagecAMP response element bindingbrain-derived neurotrophic factorhistone deacetylase inhibitorneurogenesis

Abstract 

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation- exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation- induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.

URI 

https://doi.org/10.4103/1673-5374.255974

ISSN 

1673-5374

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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