상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Anti-inflammatory Potential of Saponins from Aster tataricus via NF-κB/MAPK Activation

Authors 

X D SuHyun Jae JangC Y WangSeung Woong LeeMun Chual RhoY H KimS Y Yang

Publisher 

American Chemical Society

Issue Date 

2019

Citation 

Journal of Natural Products

Abstract 

Four new aster saponins (1?4) together with five known analogues (5?9) were isolated from Aster tataricus. The chemical structures of 1?4 were elucidated based on spectrometric and spectroscopic analysis and comparison with reported data. The potential anti-inflammatory activities of aster saponins 1?9 were evaluated subsequently by measuring lipopolysaccharide (LPS)-enhanced nitric oxide (NO) formation in murine macrophages. Among these, aster saponin B (6) exhibited the most potent inhibitory activity (IC50: 1.2 μM). Additionally, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels were dose-dependently suppressed by 6 in LPS-activated RAW 264.7 cells. Investigation of the anti-inflammatory mechanism indicated that 6 attenuated the phosphorylation and degradation of the inhibitor of NF-κB (IκB), which led to the blocking of NF-κB p65 translocation to the nucleus.

URI 

https://doi.org/10.1021/acs.jnatprod.8b00856

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)