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Title 

Anti-osteoporotic effects of kukoamine B isolated from Lycii Radicis cortex extract on osteoblast and osteoclast cells and ovariectomized osteoporosis model mice

Authors 

E ParkJ KimM C KimS YeoS ParkM JoC W ChoiH S JinSang Woo LeeW Y LiJ W LeeJ H ParkD HuhS Y Jeong

Publisher 

MDPI AG

Issue Date 

2019

Citation 

International Journal of Molecular Sciences

Keywords 

osteoporosisherbal medicinekukoamine Bosteoblastosteoclastbone mineral densityovariectomized mice

Abstract 

Osteoporosis is an abnormal bone remodeling condition characterized by decreased bone density, which leads to high risks of fracture. Previous study has demonstrated that Lycii Radicis Cortex (LRC) extract inhibits bone loss in ovariectomized (OVX) mice by enhancing osteoblast di erentiation. A bioactive compound, kukoamine B (KB), was identified from fractionation of an LRC extract as a candidate component responsible for an anti-osteoporotic e ect. This study investigated the anti-osteoporotic e ects of KB using in vitro and in vivo osteoporosis models. KB treatment significantly increased the osteoblastic di erentiation and mineralized nodule formation of osteoblastic MC3T3-E1 cells, while it significantly decreased the osteoclast di erentiation of primary-cultured monocytes derived from mouse bone marrow. The e ects of KB on osteoblastic and osteoclastic di erentiations under more physiological conditions were also examined. In the co-culture of MC3T3-E1 cells and monocytes, KB promoted osteoblast di erentiation but did not a ect osteoclast di erentiation. In vivo experiments revealed that KB significantly inhibited OVX-induced bone mineral density loss and restored the impaired bone structural properties in osteoporosis model mice. These results suggest that KB may be a potential therapeutic candidate for the treatment of osteoporosis.

URI 

https://doi.org/10.3390/ijms20112784

ISSN 

1422-0067

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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