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Title 

Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes

 

세드렐라 오도라타의 Keratinocyte 세포에서의 항염증 효과

Authors 

Han-Sol LeeJi Won ParkOk-Kyoung KwonYourim LimJung Hee KimSoo Yong KimN ZamoraK RosalesSangho ChoiSei-Ryang OhKyung Seop Ahn

Publisher 

Spandidos Publications

Issue Date 

2019

Citation 

Experimental and Therapeutic Medicine

Abstract 

Cedrela odorata L. is a native plant of the Amazon region. The bark is used in folk remedies for the treatment of diarrhea, vomiting, fever and inflammation. Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease accompanied by itching. It is a complex disease involving environmental factors and genetic factors. In the present study, the anti?inflammatory and anti?allergic effects of C. odorata L. methanol extract (COEE) on tumor necrosis factor (TNF)?α and interferon (IFN)?γ?stimulated HaCaT keratinocyte cells were investigated. ELISA and RT?PCR analysis revealed that the extract had anti?inflammatory effects, and reduced the interleukin (IL)?6 and IL?8 levels of the HaCaT cells. In addition, COEE exhibited anti?allergic effects, comprising a reduction in the thymus and activation?regulated chemokine and macrophage?derived chemokine levels. In addition, pathway analysis and comparison with Bay11?7082 indicated that these effects are due to the inhibition of nuclear factor (NF)?κB in TNF?α/IFN?γ?induced HaCaT cells. Therefore, the results of the present study suggest that COEE has anti?inflammatory and anti?allergic properties in TNF?α and IFN?γ?stimulated HaCaT cells, which are associated with the inhibition of pro?inflammatory cytokines and chemokines via the NF?κB pathway.

URI 

https://doi.org/10.3892/etm.2019.7639

ISSN 

1792-0981

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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