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Title 

Anti-photoaging effect of skin cream manufactured with ziyuglycoside I isolated from Sanguisorba officinalis on ultraviolet B-induced hairless mice

Authors 

M Y YoonE Y BaeSeung Woong LeeS H YimS Y LyH J Choi

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2019

Citation 

Bioscience Biotechnology and Biochemistry

Keywords 

Ziyuglycoside Iphotoagingwrinkle depthepidermal thicknesscollagen degradation

Abstract 

In this study, skin cream containing ziyuglycoside I isolated from Sanguisorba officinalis was manufactured and examined the protective effects of the skin cream against UVB-induced hairless mice. UVB-induced hairless mice were topically treated with the skin cream once a day for 5 weeks. Application of the skin cream did not exhibit side effect on body growth showing normal body weight and food efficiency in the mice. The skin cream treatment also was inhibited mRNA expression of interleukin (IL)-1β, matrix metalloproteinase (MMP)-2, MMP-9, and MMP-2 protein expression in the mice. Furthermore, the skin cream treatment inhibits epidermal wrinkle formation, wrinkle depth, wrinkle thickness, and collagen degradation in UVB-induced hairless mice. Therefore, the skin cream was able to play a role in the attenuation of photoaging caused by UVB irradiation via downregulation of mRNA expression of inflammatory cytokine IL-1β, MMP-2, MMP-9, and suppression of MMP-2 proteins expression.

URI 

https://doi.org/10.1080/09168451.2019.1607247

ISSN 

0916-8451

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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