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Title 

Stimulatory effects of platycodin D on osteoblast differentiation

Authors 

Y HanS W JinG H LeeJ H ChoiHyun Sun LeeY C ChungH G JeongK Y Lee

Publisher 

Wiley

Issue Date 

2019

Citation 

Journal of Cellular Biochemistry

Keywords 

K3βosteoblastplatycodin Dsirtuin 1 (SIRT1)β­catenin

Abstract 

Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. However, the effects of platycodin D on osteoblast differentiation have not been elucidated yet. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. In a molecular mechanism study, platycodin D induced β­catenin nuclear accumulation by upregulating GSK3β phosphorylation. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/β­catenin pathways. Taken together, these results suggested that platycodin D could be an effective therapeutic compound against osteoporosis because of its regulatory effects during the osteoblast differentiation.

URI 

https://doi.org/10.1002/jcb.28580

ISSN 

0730-2312

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-07-10


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