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Title 

Cytoprotective effects of an aqueous extracts from atrina pectinate meat in H2O2-induced cxidative stress in a human hepatocyte

Authors 

E J ShinE J HanH J HanKyungsook JungS J HeoE A KimK N KimS C KimM J SeoI S KwakM J KimG AhnW W Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2019

Citation 

Advances in Experimental Medicine and Biology

Keywords 

Anti-oxidantAtrina pectinateHepatocytesNrf2/HO-1 signal pathway

Abstract 

In the present study, we investigated the antioxidant activity of an aqueous extract from Atrina pectinate meat (APW) against H2O2-induced oxidative stress in a human hepatocyte. The extraction yield of APW was 30.01 ± 0.83% and which contained the highest taurine content among free amino acid contents. APW led to the high antioxidant activity showing 2,2-azino-bis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, good reducing power and oxygen radical absorbance capacity (ORAC) value. Also, the results showed that APW improved the cell viability decreased by H2O2 stimulation as well as the reduction of intracellular reactive oxygen species (ROS) generation in hepatocytes. Additionally, APW up-regulated the production of antioxidant mechanisms related enzymes such as catalase and superoxide dismutase (SOD), compared to the only H2O2-treated hepatocytes. Moreover, APW increased the expressions of nuclear Nrf2 and cytosolic HO-1 in H2O2-treated hepatocytes. Interestingly, the treatment of ZnPP, a HO-1 inhibitor abolished the cell viability and intracellular ROS generation induced by APW treatment. In conclusion, this study suggests that APW protects H2O2 induced oxidative stress via up-regulating of Nrf2/HO-1 signal pathway in hepatocytes.

URI 

https://doi.org/10.1007/978-981-13-8023-5_58

ISSN 

0065-2598

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-10-29


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