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Title 

Antioxidant effects of an alcalase hydrolysate from Batillus cornutus meat

Authors 

H J HanE J HanE J ShinKyungsook JungS J HeoE A KimK N KimI S KwakS C KimM J SeoM J KimG AhnW W Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2019

Citation 

Advances in Experimental Medicine and Biology

Keywords 

Batillus cornutus meatTaurineAntioxidant effectVero cell

Abstract 

Batillus cornutus (B. cornutus) is one of the gastropoda, which are distributed along the coast of China, Japan and South Korea and northeast area. In this study, we first identified the antioxidant effects of a B. cornutus meat (BM) enzymatic hydrolysate in H2O2-treated Vero cells. First of all, we prepared an Alcalase hydrolysate from BM (BMA) and revealed a high taurine content. Also, taurine rich BMA dose-dependently increased 2,2-azino-bis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, reducing power and the higher oxygen radical absorbance capacity (ORAC) value. In addition, BMA significantly increased the cell viability via the down-regulation of intracellular reactive oxygen species (ROS) production, as well as the decreased formation of apoptotic bodies and sub-G1 DNA population in H2O2-treated Vero cells. Furthermore, BMA increased the expression of the anti-apoptotic molecule, Bcl-2, and decreased the expressions of Bax, p53 and cleaved PARP, all of which are pro-apoptotic molecules, in H2O2-treated Vero cells. Based on these results, this study suggests that BMA may be used as a potential protector on damage caused by oxidative stress.

URI 

https://doi.org/10.1007/978-981-13-8023-5_57

ISSN 

0065-2598

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-10-29


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