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Title 

An aqueous extract of Octopus ocellatus meat protects hepatocytes against H2O2-induced oxidative stress via the regulation of Bcl-2/Bax signaling

Authors 

W W LeeE J HanS J OhE J ShinH J HanKyungsook JungS J HeoE A KimK N KimI S KwakM J KimG Ahn

Publisher 

Springer Verlag (Germany)

Issue Date 

2019

Citation 

Advances in Experimental Medicine and Biology

Keywords 

Aqueous extractOctopus ocellatus meatProtective effectTaurine

Abstract 

Octopus ocellatus meat (OM) is well known as a plentiful protein source. In this study, we evaluated the hepatoprotective effect of an aqueous extract of OM (OMA) against H2O2-triggered oxidative stress in human hepatocytes. First of all, taurine rich OMA showed a good ORAC value and reducing power and it was similar with that of ascorbic acid, which is known as a strong antioxidant. Also, OMA significantly improved H2O2-decreased cell viability by reducing the generation of intracellular reactive oxygen species (ROS) in hepatocytes. Interestingly, the stimulation of H2O2-induced the formations of apoptotic bodies and sub-G1 DNA content, whereas they were inhibited by the treatment with OMA. Furthermore, OMA regulated the protein expression levels of apoptotic molecules, such as Bax and Bcl-2. Taken together, this study suggests that OMA, which contains an abundant amount of taurine, protects hepatocytes from H2O2-triggered oxidative stress and might be a functional food material with hepatoprotective effects.

URI 

https://doi.org/10.1007/978-981-13-8023-5_54

ISSN 

0065-2598

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-10-29


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