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Title 

An aqueous extract from Batillus cornutus meat protects against H2O2-mediated cellular damage via up-regulation of Nrf2/HO-1 signal pathway in chang cells

Authors 

W W LeeH J HanE J HanE J ShinKyungsook JungS J HeoI S KwakS C KimM J SeoM J KimE A KimS H ChaG Ahn

Publisher 

Springer Verlag (Germany)

Issue Date 

2019

Citation 

Advances in Experimental Medicine and Biology

Keywords 

Antioxidant effectBatillus cornutus meatCellular oxidative stressNrf2/HO-1 signal pathwayProtective effectTaurine

Abstract 

In this study, we evaluated the protective effects of an aqueous extract from Batillus cornutus meat (BM) against cellular oxidative damage caused by hydrogen peroxide (H2O2) in human hepatocyte, Chang cells. First, we prepared an aqueous extract of BM meat (BMW) showing the highest taurine content among free amino acid contents. BMW led to high antioxidant activity showing 2,2-azino-bis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, good reducing power and an oxygen radical absorbance capacity (ORAC) value. Also, BMW improved cell viability that was diminished by H2O2 exposure, as it reduced the generation of intracellular reactive oxygen species (ROS) in Chang cells. In addition, BMW up-regulated the production of antioxidant enzymes, such as catalase and superoxide dismutase (SOD), compared to H2O2-treated Chang cells lacking BMW. Moreover, BMW induced the expressions of nuclear Nrf2 and cytosolic HO-1 in H2O2-treated Chang cells. Interestingly, the treatment of ZnPP, HO-1 inhibitor, abolished the improvement in cell viability and intracellular ROS generation mediated by BMW treatment. In conclusion, this study suggests that BMW protects hepatocytes against H2O2-mediated cellular oxidative damage via up-regulation of the Nrf2/HO-1 signal pathway.

URI 

https://doi.org/10.1007/978-981-13-8023-5_53

ISSN 

0065-2598

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-10-29


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