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Title 

Enhanced production of shikonin by Lithospermum erythrorhizon cells immobilized in polyurethane foam matrices

Authors 

Young Hoon ParkWeon Taek SeoJang Ryol Liu

Issue Date 

1990

Citation 

Journal of Fermentation and Bioengineering, vol. 70, no. 5, pp. 317-321

Keywords 

shikoninimmobilized cellplant celllithospermum erythrorhizon

Abstract 

Production of shikonin by Lithospermum erythrorhizon cells immobilized in polyurethane foam matrices was investigated. The cells were effectively entrapped inside the polymer matrices prepared in a cubic form with a lateral length of 0.5 cm. They proliferated further by incubation and resulted in immobilized and resulted in immobilized polymer foam cubes which were fully packed with cell aggregates. Shikonin production was observed to increase significantly when the immobilized cells were used. It was excreted by the cells and directly adsorbed, by hydrophobic interaction, to the polymer site. The product could be recovered, after the cells were separated, by direct solvent extraction from the shikonin-adsorbed polyurethane matrices. It is more interesting to note that a single-stage culture with immobilized L. erythrorhizon cells yielded higher shikonin productivity than the conventional two-stage culture system, which is considered to be of practical importance for industrial applications.

ISSN 

0385-6380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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