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Title 

Glucose-limited fed-batch culture of Escherichia coli for production of recombinant human interleukin-2 with the DO-stat method

Authors 

Dong Jin SeoBong Hyun ChungYoung Bo HwangYoung Hoon Park

Issue Date 

1992

Citation 

Journal of Fermentation and Bioengineering, vol. 74, no. 3, pp. 196-198

Keywords 

glucosefed batch cultureglucose limited culturehuman interleukinsrecombinant DNAbatch cell cultureinterleukin 2recombinant interleukin 2escherichia colihuman

Abstract 

Fed-batch culture employing the DO-stat method was carried out to produce recombinant human interleukin-2 in Escherichia coli. The concentration of interleukin-2 and final cell density in the fed-batch culture were 1.02 g/l and 60 OD (optical density), respectively. This represents a significant improvement in interleukin-2 production and final cell density over the equivalent values of batch fermentation.

ISSN 

0385-6380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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