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Title 

Isolation of vindoline from Catharanthus roseus by supercritical fluid extraction

Authors 

Kyu-Min SongSang-Woo ParkWon-Hi HongHuen LeeSang Soo KwakJang Ryol Liu

Publisher 

American Chemical Society

Issue Date 

1992

Citation 

Biotechnology Progress, vol. 8, no. 6, pp. 583-586

Keywords 

supercritical fluid extractioncatharanthus roseusvindoline isolationvindolineisolation and purification

Abstract 

Vindoline was extracted from the leaves of Catharanthus roseus over the ranges of 35-70 °C and 100-300 bar using supercritical carbon dioxide with and without the addition of 3 wt % ethanol as a cosolvent. The vindoline contents in the extracts were determined by HPLC and identified by LC/MS. The remarkable highest vindoline concentration, 58 wt %, was obtained at the lowest temperature, 35 °C, and the highest pressure, 300 bar, of this study. The use of a cosolvent only slightly improved the extraction yields or selectivities at some experimental conditions.

ISSN 

8756-7938

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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