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Title 

Comparative studies of adriamycion and 28-deacetyl sedanin on in vitro growth inhibition of human cancer cell lines

Authors 

Hwan Mook KimGoo Taeg OhSang Bae HanDong Ho HongBang Yeon HwangYoung Ho KimJung Joon Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1994

Citation 

Archives of Pharmacal Research, vol. 17, no. 2, pp. 100-103

Keywords 

28 deacetylsendanin28-deacetylsendanincell culturecomparative studyhumanhumanstumor cells, cultured

Abstract 

The limonoid compound (28-deacetyl sendanin) isolated from the fruit of Melia toosendan SIEB. et ZUCC. was evaluated on anticancer activity. According to a standard in vitro cytotoxicity assay, eight human cancer cell lines and SRB assay were introduced for present evaluation. As a positive standard, adriamycin was tested in parallel. The cell lines were originated from six different organs. In view of dose-response profiles to 28-deacetyl sendanin, the most sensitive cells were SF-539 and PC-3 which were derived from CNS and prostate, respectively. In contrast, all the cell lines responded similarly to adriamycin to give rise to nearly identical dose-response profiles. By comparison of Gl50 between 28-deacetyl sendanin and adriamycin, six cell lines were more sensitive to 28-deacetyl sendanin and two were more resistant. As a result, 28-deacetyl sendanin had more sensitive and selective inhibitory effects on in vitro growth of human cancer cell lines in a comparison with adriamycin.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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