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Title 

Direct exposure to 2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD) increases infectivity of human erythrocytes to a malarial parasite

Authors 

Hwan Mook KimIn Pyo ChoiM P Holsapple

Publisher 

Elsevier

Issue Date 

1994

Citation 

Life Sciences, vol. 54, no. 12, pp. 215-220

Keywords 

2,3,7,8 tetrachlorodibenzo para dioxinadenosine triphosphatase (calcium)adenosine triphosphatase inhibitororthovanadic acidprotein tyrosine phosphataseerythrocytehumanhuman cellnormal humanparasitemia

Abstract 

Direct exposure to 10 nM 2,3,7,8-TCDD caused a 75% increase and a 2-fold increase in the infectivity of isolated human erythrocytes to P. falciparum after 48 hours when the parasites were in an unsynchronized or synchronized state of growth, respectively. Treatment of human erythrocytes with 10 μM sodium orthovanadate (NaOV), an inhibitor of plasma membrane Ca-ATPase and phosphotyrosine phosphatase, decreased parasitemia by 30%. Co-treatment of RBCs with TCDD and NaOV completely blocked the TCDD-induced increase in parasitemia. Because erythrocytes are anucleated, these results are discussed as evidence for biochemical changes by TCDD without requiring the activation of gene products.

ISSN 

0024-3205

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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