상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Analysis of taxol and cephalomannine in Cheju island yew(Taxus cuspidata S. et Z.)

 

제주도 주목(Taxus cuspidata S. et Z.)의 taxol 및 cephalomannine의 함량분석

Authors 

Sang Soo KwakMyung-Suk ChoiKyung-Soo KoYoung-Goo ParkJang Ryol Liu

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1995

Citation 

Korean Journal of Pharmacognosy, vol. 26, no. 2, pp. 116-121

Keywords 

anticancer agentcephalomanninetaxaceaetaxanetaxoltaxus cuspidatayewdrug determinationmass spectrometry

Abstract 

To seek for a stable supply source of taxol as an anticancer agent urgently needed for the treatment of ovarian cancer, the concentrations of taxol and cephalomannine in bark and needles of 37 yew (Taxus cuspidata S. et Z.) trees grown in 6 locations of Cheju Island were analyzed by using HPLC. A considerable variation in the content was observed in plant part and the location. The average taxol content in the needles (220.3 ± 56 μg per g dry wt) was ca. 4 times higher than that in the bark, whereas the content of cephalomannine in the needles (353 ± 141 μg) was ca. 5 times higher than that in the bark. Particularly, even within Cheju Island, needles from trees grown near the coast including Sogwipo area contained much higher taxol contents than needles from trees grown at mountain locations, indicating that taxane level is affected by environmental effects. Taxol in the needles was confirmed by electrospray mass spectrometry. These results suggest that the needles of yew trees growing in Cheju Island may provide a renewable source for taxol.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)