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Title 

Isolation of modulators for multidrug resistance from the fruits of Evodia officinalis

 

약용식물 오수유로부터 다제약제 내성 조절물질의 분리

Authors 

Sung Woo LeeBang Yeon HwangSe Eun KimHwan Mook KimYoung Ho KimKyong Soon LeeJung Joon LeeJai-Seup Ro

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1995

Citation 

Korean Journal of Pharmacognosy, vol. 26, no. 4, pp. 344-348

Keywords 

cytotoxic activitiesevodia officinalisevodiaminemultidrug resistancerutaecarpineevodia officinalis extractdrug isolation

Abstract 

Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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