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Title 

GERI-BP001 compounds, new inhibitors of Acyl-CoA : cholesterol acyltransferase from Aspergillus fumigatus F37

Authors 

Tae Sook JeongSung Uk KimKwang Hee SonByoung-Mog KwonYoung Kook KimMyung-Un ChoiSong Hae Bok

Publisher 

Nature Publishing Group

Issue Date 

1995

Citation 

Journal of Antibiotics, vol. 48, no. 8, pp. 751-756

Keywords 

cholesterol acyltransferaseenzyme inhibitorgeri bp001 ageri bp001 bgeri bp001 maspergillus fumigatusenzyme inhibitorssterol o-acyltransferase

Abstract 

GERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 μM, respectively.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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