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Title 

Suberitenones A and B: Sesterterpenoids of an unprecedented skeletal class from the Antarctic sponge Suberites sp.

Authors 

Jongheon ShinYoungwan SeoJung-Rae RhoEunjoo BaekByoung-Mog KwonTae Sook JeongSong Hae Bok

Publisher 

American Chemical Society

Issue Date 

1995

Citation 

Journal of Organic Chemistry, vol. 60, no. 23, pp. 7582-7588

Keywords 

suberitenone asuberitenone bunclassified drugarticledrug isolationnuclear magnetic resonancesponge

Abstract 

Suberitenones A (1) and B (2), sesterterpenoids of an unprecedented skeletal class, have been isolated from the Antarctic sponge Suberites sp. Structures of these compounds have been determined by combined spectral and chemical studies. Absolute stereochemistry has been assigned on the basis of a combination of the Kusumi and Kakisawa modification of Mosher's method and CD measurement. Suberitenone B inhibited the cholesteryl ester transfer protein (CETP), which mediates the transfer of cholesteryl ester and triglyceride between high-density lipoproteins and low-density lipoproteins. In addition, suberitenone A has been chemically transformed to suberiquinol (10), a hydroquinone derivative.

ISSN 

0022-3263

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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