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Title 

Inhibition of PDGF-induced phospholipase D but not phospholipase C activation by herbimycin A

Authors 

Bo Yeon KimSoon Cheol Ahn오혜경Hyun Sun Lee민태익Hyune Mo RhoJong Seog Ahn

Publisher 

Elsevier

Issue Date 

1995

Citation 

Biochemical and Biophysical Research Communications, vol. 212, no. 3, pp. 1061-1067

Keywords 

herbimycin aphospholipase cphospholipase dplatelet derived growth factoranimal cellcell strain 3t3controlled studyenzyme activationenzyme inhibitionnonhuman

Abstract 

It is known that PDGF-induced phospholipase D (PLD) activation occurs downstream of phospholipase Cγ1 (PLC-γ1) activation. Herbimycin A, a specific inhibitor of Src family tyrosine kinase, dose-dependently inhibited PDGF-induced PLD activation (IC50 of 8 μg/ml) without affecting PLC-γ1 activation and significantly reduced PDGF-induced tyrosine phosphorylations of 40-46 kD and 60 kD proteins in PLC-γ1-overexpressing NIH 3T3γ1 cells. These results suggest that PLC activation is necessary but not sufficient for PDGF-induced PLD activation. Tyrosine phosphorylation of p40-p46 and p60 is thought to be involved in PDGF-induced activation of PLD but not of PLC.

ISSN 

0006-291X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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