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Title 

Regulation of transforming growth factor-β1 expression by the hepatitis B virus(HBV) X transactivator : role in HBV pathogenesis

Authors 

Young Do YooH UedaKeunchil ParkK C FlandersYoung Ik LeeG JaySeong-Jin Kim

Publisher 

American Society for Clinical Investigation

Issue Date 

1996

Citation 

Journal of Clinical Investigation, vol. 97, no. 2, pp. 388-395

Keywords 

hepatitis B virushepatocellular carcinomaimmunohistochemistryTGF-β1transcriptionhepatitis b antigentranscription factortransforming growth factor beta1gene expression regulationliver Neoplasms

Abstract 

TGF-β1 has been implicated in the pathogenesis of liver disease. The high frequency of detection of the hepatitis B virus X (HBx) antigen in liver cells from patients with chronic hepatitis, cirrhosis, and liver cancer suggested that expression of HBx and TGF-β1 may be associated. To test this possibility, we examined the expression of TGF-β1 in the liver of transgenic mice expressing the HBx gene. We show that the patterns of expression of TGF-β1 and Hbx protein are similar in these mice and that HBx activates transcription of the TGF-β1 gene in transfected hepatoma cells. The cis-acting element within the TGF-β1 gene that is responsive to regulation by Hbx is the binding site for the Egr family of transcription factors. We further show that the Egr-1 protein associates with the HBx protein, allowing HBx to participate in the transcriptional regulation of immediate-early genes. Our results suggest that expression of Hbx might induce expression of TGF-β1 in the early stages of infection and raise the possibility that TGF-ßl may play a role in hepatitis B virus pathogenesis.

ISSN 

0021-9738

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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