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Title 

Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III

Authors 

Yeon Jeong KimJong Hoon ParkKyung Sook KimJi Eun ChangJung Hun KohMyung Hee KimDong Hyo ChungTai Wha ChungIn Seong ChoeYoung Choon LeeChul Ho Kim

Publisher 

Elsevier

Issue Date 

1996

Citation 

Gene, vol. 170, no. 2, pp. 281-283

Keywords 

Placental libraryPromoter elementTranscription factorgalactosyltransferaseinsulinn acetylglucosaminyltransferasetranscription factor ap 2consensus sequencecyclic amp responsive elementdna flanking region

Abstract 

We have isolated and characterized the immediate (1651 bp) 5′-flanking region of the gene (GnT-III) encoding N-acetylglucosaminyltransferase III (GnT-III) from a human placental genomic library. Analysis of promoter elements shows a similarity to the 5′-flanking region of murine 1,4-galactosyltransferase. The sequence lacks obvious TATA elements and CCAAT boxes; however, putative regulatory sites, including 2 potential cAMP-response regulatory elements (CRE), 11 insulin-response element consensus sequences (IRE), 7 potential AP-2-binding sites, 2 SP1 consensus sequences (GC boxes) and 2 sequences similar to the half-palindromic glucocorticoid-responsive element (GRE), are present.

ISSN 

0378-1119

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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