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Title 

Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody(MabA34) specific for human plasma apolipoprotein A-I

Authors 

Ju Won KwakDong-Ik LeeByung-Kwon ChoiWon Kyung ChoSang-Han LeeYong-Bok ParkMoon Hi Han

Publisher 

Elsevier

Issue Date 

1996

Citation 

Gene, vol. 173, no. 2, pp. 257-259

Keywords 

Apo A-IDNA sequencingHDL cholesterolhigh-density lipoproteinsimmunoglobulin Fabpolymerase chain reactionrecombinant DNAapolipoprotein a1complementary dnahigh density lipoprotein

Abstract 

We have determined the nucleotide (nt) sequences encoding the heavy (H)- and light (L)-chains of the Fab fragment of a murine monoclonal antibody, MabA34 (γl, κ), which is specific for human plasma apolipoprotein A-I of high-density lipoproteins. The variable (V) regions of the H- and L-chains were revealed to be members of mouse I-I-chain subgroup II(A) and κ L-chain subgroup II, respectively. A few unusual amino acids in the V region of the H-chain, and nt residues probably introduced by somatic mutations from germline genes were also identified.

ISSN 

0378-1119

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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