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Title | Benzastatins A, B, C and D : new free radical scavengers from Streptomyces nitrosporeus 30643 I. taxonomy, fermentation, isolation, physico-chemical properties and biological activities |
Authors | Won Gon Kim; Jong Pyung Kim; Chang Jin Kim; K H Lee; Ick Dong Yoo |
Publisher | Nature Publishing Group |
Issue Date | 1996 |
Citation | Journal of Antibiotics, vol. 49, no. 1, pp. 20-25 |
Keywords | benzastatin a; benzastatin b; benzastatin c; benzastatin d; glutamic acid; scavenger; unclassified drug; animal tissue; cell line; controlled study |
Abstract | In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton, and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of Streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 μM, respectively. |
ISSN | 0021-8820 |
Appears in Collections | |
Registered Date |
2019-05-02 |
