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Title 

Benzastatins A, B, C and D : new free radical scavengers from Streptomyces nitrosporeus 30643 I. taxonomy, fermentation, isolation, physico-chemical properties and biological activities

Authors 

Won Gon KimJong Pyung KimChang Jin KimK H LeeIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

1996

Citation 

Journal of Antibiotics, vol. 49, no. 1, pp. 20-25

Keywords 

benzastatin abenzastatin bbenzastatin cbenzastatin dglutamic acidscavengerunclassified druganimal tissuecell linecontrolled study

Abstract 

In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton, and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of Streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 μM, respectively.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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