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Title 

Cytotoxic benzyl dihydroflavonols from Cudrania tricuspidata

Authors 

In Kyoung LeeChang Jin KimK S SongHwan Mook KimH KoshinoM UramotoIck Dong Yoo

Publisher 

Elsevier

Issue Date 

1996

Citation 

Phytochemistry, vol. 41, no. 1, pp. 213-216

Keywords 

6,8-di-p-hydroxybenzyltaxifolin6-p-hydroxybenzyltaxifolin8-p-hydroxybenzyltaxifolincudrania tricuspidatacytotoxicitydihydroflavonolsgericudraninsmoraceaeP-hydroxybenzyldihydroflavonolsstem bark

Abstract 

Three new dihydroflavonols, gericudranins A-C were isolated from the stem bark of Cudrania tricuspidata. They were identified as 6,8-di-p-hydroxybenzyltaxifolin, 8-p-hydroxybenzyltaxifolin and 6-p-hydroxybenzyltaxifolin, respectively, by means of spectral studies. These compounds were cytotoxic to human tumor cell lines, such as CRL 1579 (skin), LOX-IMVI (skin), MOLT-4F (leukemia), KM12 (colon) and UO-31 (renal) in culture, with ED50 values of 2.7-31.3 μg ml-1.

ISSN 

0031-9422

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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