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Title 

Bestatin analogue from Streptomyces neyagawaensis SL-387

Authors 

Myung Chul ChungHo Jae LeeHyo Kon ChunChoong Hwan LeeSu-Il KimYung Hee Kho

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

1996

Citation 

Bioscience Biotechnology and Biochemistry, vol. 60, no. 5, pp. 898-900

Keywords 

aminopeptidase Nbestatin analogueinhibitorbestatinMR 387Astreptomycesstreptomyces neyagawaensis

Abstract 

A bestatin analogue, (2S,3R)-3-amino-2-hydroxy-4- phenylbutanoyl-L- valine (AHPA-Val), from the culture filtrate of Streptomyces neyagawaensis SL-387 was obtained in a chemically defined medium containing DL- 3-amino-3- phenylpropionic acid. AHPA-Val was 6 times (IC50=1.2 μg/ml) as strong as bestatin (IC50=7.0 μg/ml) against porcine kidney microsomal aminopeptidase N, and 4 times (5.6 μg/ml) as strong as bestatin (IC50= 20.7 μg/ml) against amino-peptidase N of human metastatic fibrosarcoma HT1080. To the best of our knowledge, this is the first report on the microbial production of AHPA-Val.

ISSN 

0916-8451

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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