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Title 

Inhibition of phospholipase Cγ1 activity by amentoflavone isolated from Selaginella tamariscina

Authors 

Hyun Sun LeeWon Keun OhBo Yeon KimSoon Cheol AhnDae Ook KangDong In ShinJinwoong KimTae Ick MheenJong Seog Ahn

Publisher 

Georg Thieme Verlag

Issue Date 

1996

Citation 

Planta Medica, vol. 62, no. 4, pp. 293-296

Keywords 

amentoflavonekampo medicinesphosphoinositides (PI)-turnoverphospholipase Cγ1 inhibitorselaginella tamariscinaselaginellaceaephospholipase cselaginella tamariscina extractenzyme inhibition

Abstract 

Amentoflavone was isolated as an inhibitor of phospholipase Cγ1 (PLCγ1) and phosphoinositides (PI)-turnover in PLCγ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1) from Selaginella tamariscina (Selaginellaceae) together with other related biflavonoids, isocryptomerin and cryptomerin B. Only amentoflavone inhibited the PLCγ1 activity with an IC50 of 29 μM and the formation of total inositol phosphates (IP(t) in PDGF-stimulated NIH3T3γ1 with an IC50 of 9.2 μM but did not show inhibitory activity against protein kinase C. Isocryptomerin and cryptomerin B did not show inhibitory activity against PLCγ1 at the concentration of 150 μ M, and did not inhibit IP(t) production in PDGF-induced NIH3T3γ1 at the concentration of 180 μM.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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